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Test Code CARNU Carnitine, Random, Urine

Reporting Name

Carnitine, U

Useful For

Evaluation of patients with a clinical suspicion of a wide range of conditions including organic acidemias and fatty acid oxidation disorders

 

Monitoring carnitine treatment

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 1.5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 365 days
  Refrigerated  72 hours

Reference Values

FREE CARNITINE:

77-214 nmol/mg of creatinine

 

TOTAL CARNITINE:

180-412 nmol/mg of creatinine

 

RATIO:

Acylcarnitine to free carnitine: 0.7-3.4

Day(s) Performed

Tuesday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82379

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CARNU Carnitine, U 100428-2

 

Result ID Test Result Name Result LOINC Value
27121 Total 17866-5
27122 Free (FC) 17867-3
15789 AC/FC Ratio 43576-8
21550 Interpretation 59462-2

Report Available

3 to 9 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Highlights

Carnitine levels are disturbed in primary disorders of the carnitine cycle, or secondary disturbances of carnitine metabolism due to other biochemical disorders.

 

While plasma or serum carnitine is reduced in primary carnitine deficiency, urine carnitine may be normal or elevated.

 

Dietary intake (meat, carnitine supplementation) may cause increased carnitine values.

 

Abnormal results are accompanied by detailed interpretation including recommendations for follow-up testing.

Method Name

Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS)