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Test Code CYCLO Cyclosporine, Blood

Performing Laboratory

NorDx

Reference Values

RECOMMENDED TARGET RANGES FOR NEORAL MONITORING:

Cyclosporine C0 (TROUGH) for renal transplant:
<3 months post-transplant: 235-310 ng/mL
3-12 months post-transplant: 160-235 ng/mL
>12 months post-transplant: 60-135 ng/mL
Potentially toxic value: >400 ng/mL

Cyclosporine C2 (PEAK) for renal transplant:
<3 months post-transplant: 770-1170 ng/mL
3-12 months post-transplant: 670-1070 ng/mL
>12 months post-transplant: 470-770 ng/mL

Cyclosporine C0 (TROUGH) for non-renal transplant: 100-400 ng/mL
Potentially toxic value: >400 ng/mL

Day(s) Test Performed

Monday through Sunday (Must be received by 12 noon for same day results.)

Methodology

High performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC-MS/MS) 

Specimen Requirements

Draw blood in a lavender-top (EDTA) tube, and send 4.5 mL (minimum volume: 0.3 mL) of EDTA whole blood refrigerated. Do not centrifuge. Send in original VACUTAINER®.

Note: 1. Therapeutic ranges apply to trough specimens collected just prior to a.m. dose.
Peak ranges apply to peak specimens collected 2 hours post dose.

2. This test was developed and its performance characteristics determined by NorDx. It has not been cleared or approved by the U.S. Food and Drug Admnistration (FDA).

Test Classification and CPT Coding

 80158