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HelpTest Code TRPTSE Tryptase, Total
Useful For
Valuation of individuals with suspected mast cell activation, which may occur as a result of anaphylaxis or allergen challenge
Evaluation of patients with suspected mast cell activation syndrome
Evaluation of patients with suspected cutaneous or systemic mastocytosis
Specimen Requirements
Collection Container/Tube:
Preferred: Serum
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2mL preferred, 1.5mL minimum
Collection Instructions: Centrifuge within 2 hours and aliquot serum into a plastic vial.
Specimen Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen (preferred) | 14 days |
| Refrigerated | 7 days |
Reference Values
<11.5 ug/l
Interpretation
Transient tryptase concentrations greater than or equal to 11.5 ug/l may be consistent with mast cell activation in the context of anaphylaxis or allergen challenge; measurement of tryptase in specimens obtained 1 to 6 hours and at least 24 hours after the episode may be useful in demonstrating a return to baseline concentrations.
Basal tryptase concentrations greater than or equal to 11.5 ug/l may be consistent with cutaneous mastocytosis.
Basal tryptase concentrations greater than or equal to 20 ng/mL may be consistent with systemic mastocytosis.
Method
Fluorescence Enzyme Immunoassay (FEIA)
CPT
83520
Performing Laboratory
MaineGeneral Medical Center